Sonic vibration stimulation regulates the balance between bone formation and adipogenesis in human bone marrow-derived mesenchy

SUMMARY
Osteoporosis can be associated with the disordered balance between osteogenesis and adipogenesis of bone marrow-derived mesenchymal stem cells (BM-MSCs). The mechanical stimulation can direct the lineage commitment of MSCs by biasing cell fate in favor of osteogenesis, suggesting that MSCs may sense the vibratory frequencies.
BM-MSCs were subjected to acoustic-frequency vibratory stimulation (AFVS) at frequencies of 0, 30, 400 and 800 Hz and induced toward osteogenic or adipogenic-specific lineage. BM-MSCs showed a frequency-dependent response to acoustic vibration. In other words, AFVS at 800 Hz was the most favorable for osteogenic differentiation and simultaneously suppressed adipogenesis. Thus, acoustic vibration could potentially become a novel means to prevent and treat osteoporosis.